Evaluation of urine gamma-glutamyl transpeptidase-to-creatinine ratio as a diagnostic tool in an experimental model of aminoglycoside-induced acute renal failure in the dog

The potential diagnostic utility of the urine gamma-glutamyl transpeptidase (GGT)-to-creatinine ratio was evaluated in an experimental canine model of aminoglycoside-induced nephrotoxicity. A therapeutic dosage of gentamicin resulted in a twofold increase in the mean urine GGT-to-creatinine ratio that was not associated with clinically significant nephrotoxicity. In dogs each given a nephrotoxic dosage of gentamicin, an increase in mean urine GGT-to-creatinine ratios approximately three times baseline values preceded clinically significant abnormalities in serum creatinine, urine specific gravity, and urine protein-to-creatinine ratio. The urine GGT-to-creatinine ratio appears superior as an early indicator of aminoglycoside-induced nephrotoxicity. Further studies in canine clinical cases are warranted.

This article has been cited by other articles:

				T. Inoue, J. C. Ko, R. E. Mandsager, M. E. Payton, D. S. Galloway, and D. N. Lange Efficacy and safety of preoperative etodolac and butorphanol administration in dogs undergoing ovariohysterectomy. J. Am. Anim. Hosp. Assoc., May 1, 2006; 42(3): 178 - 188. [Abstract] [Full Text] [PDF]