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Journal of the American Animal Hospital Association, Vol 33, Issue 2, 126-128
Copyright © 1997 by American Animal Hospital Association

Articles

Hepatocellular necrosis associated with the subcutaneous injection of an intranasal Bordetella bronchiseptica-canine parainfluenza vaccine

K Toshach, MW Jackson, and RR Dubielzig

A three-year-old wire fox terrier inadvertently was given an intranasal Bordetella bronchiseptica and canine parainfluenza vaccine subcutaneously. The dog subsequently developed both a local inflammatory reaction at the injection site and acute, nonseptic hepatocellular degeneration and necrosis. The patient was treated successfully with intravenous fluids and amikacin. Two months after the injection, the serum bile acid concentrations and hepatic histopathology indicated the presence of continued hepatocellular disease.




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Copyright © 1997 by the American Animal Hospital Association.