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Journal of the American Animal Hospital Association, Vol 34, Issue 6, 457-461
Copyright © 1998 by American Animal Hospital Association

Articles

The effect of intralesional bleomycin on canine acanthomatous epulis

K Yoshida, Y Watarai, Y Sakai, T Yanai, T Masegi, and T Iwasaki

Four dogs with recurrent acanthomatous epulis (AE) were injected with bleomycin (5 mg) intralesionally once a week. In three cases, tumors were clinically indistinguishable within three-to-eight weeks. In the fourth case, the tumor disappeared after 10 weekly injections. Through the administration period of bleomycin, no adverse reactions were recognized in any case. Electron microscopic examination together with a decrease in the percentage of mitotic cells implied that bleomycin might inhibit deoxyribonucleic acid (DNA) synthesis of tumor cells.


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D. M. Vail and D. H. Thamm
Cytotoxic Chemotherapy: New Players, New Tactics
J. Am. Anim. Hosp. Assoc., July 1, 2005; 41(4): 209 - 214.
[Abstract] [Full Text] [PDF]


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