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Journal of the American Animal Hospital Association, Vol 35, Issue 1, 56-61
Copyright © 1999 by American Animal Hospital Association

Articles

Platelet-associated immunoglobulin (antiplatelet antibody) in canine Rocky Mountain spotted fever and ehrlichiosis

CB Grindem, EB Breitschwerdt, PC Perkins, LD Cullins, TJ Thomas, and BC Hegarty

Antiplatelet antibodies were detected in the sera of dogs with naturally occurring and experimentally induced Rickettsia rickettsii and Ehrlichia canis infections. This is the first known report documenting elevated platelet-associated immunoglobulin (PAIg) titers in Rocky Mountain spotted fever (RMSF) infections. In the naturally occurring RMSF infections and ehrlichiosis, the antibodies persisted for weeks or months, even when the platelet counts had normalized. Results of this study indicate an immunological component for rickettsial thrombocytopenia. Therefore, current therapeutic recommendations, especially regarding avoiding the use of immunosuppressive drugs in patients with rickettsial diseases, need to be critically reviewed.


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H. L. Heeb, M. J. Wilkerson, R. Chun, and R. R. Ganta
Large Granular Lymphocytosis, Lymphocyte Subset Inversion, Thrombocytopenia, Dysproteinemia, and Positive Ehrlichia Serology in a Dog
J. Am. Anim. Hosp. Assoc., July 1, 2003; 39(4): 379 - 384.
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