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Journal of the American Animal Hospital Association, Vol 35, Issue 3, 236-239
Copyright © 1999 by American Animal Hospital Association

Articles

Mitoxantrone and cyclophosphamide combination chemotherapy for the treatment of various canine malignancies

CJ Henry, MS Buss, KA Potter, and KJ Wardrop

Thirteen dogs with histopathologically confirmed malignancies were treated with mitoxantrone and cyclophosphamide combination therapy. One to four doses were administered at 21-day intervals. Recombinant human granulocyte colony-stimulating factor was administered to ameliorate myelosuppression in dogs with neutrophil nadirs less than 1,000/microl. While the protocol appears to be safe for use in tumor-bearing dogs, an advantage over mitoxantrone single-agent protocols in terms of tumor response was not demonstrated in this initial pilot study.


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J. Lawrence, L. Forrest, W. Adams, D. Vail, and D. Thamm
Four-Fraction Radiation Therapy for Macroscopic Soft Tissue Sarcomas in 16 Dogs
J. Am. Anim. Hosp. Assoc., May 1, 2008; 44(3): 100 - 108.
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