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Articles |
A 10-year-old, female shih tzu was diagnosed as having myelodysplastic syndrome (MDS) based on the presence of a nonregenerative anemia, dysplastic changes in the three hematopoietic cell lines, a normal to hypercellular bone marrow, and less than 30% blast cells of all nucleated cells in the bone marrow. Low-dose aclarubicin, a differentiation-induction therapy for MDS and atypical leukemias in humans, was administered. Hematological improvement was observed, and the dog lived for 809 days after the first presentation.
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J. T. Blue Myelodysplasia: Differentiating Neoplastic from Nonneoplastic Syndromes of Ineffective Hematopoiesis in Dogs Toxicol Pathol, January 1, 2003; 31(1_suppl): 44 - 48. [Abstract] [PDF] |
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