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Two-Dimensional and M-Mode Echocardiographic Predictors of Disease Severity in Dogs With Congenital Subaortic Stenosis

From the Department of Medicine and Epidemiology (Oyama, Thomas), College of Veterinary Medicine, University of California, Davis, California 95616 and Cardiology Northwest (Oyama), 10629 Southwest Barbur Boulevard, Portland, Oregon 97219.

Address all reprint requests to Dr. Oyama.

Echocardiographic studies from 50 dogs with congenital subaortic stenosis were examined. The degree of concentric, left-ventricular hypertrophy as assessed by M-mode measurement demonstrated a positive relationship (P <0.05) to disease severity. However, the clinical utility of these measures is hindered by a large amount of individual variation (r²=0.243 to 0.473). Two-dimensional ultrasound was used to compare the cross-sectional area of the left-ventricular outflow tract to the cross-sectional area of the aortic root. The ratio of these two areas demonstrated a strong inverse relationship (P=0.001; r²=0.778) with disease severity. This ratio provides a method of estimating severity of disease by two-dimensional echocardiography.