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Journal of the American Animal Hospital Association 38:225-230 (2002)
© 2002 American Animal Hospital Association

Case Report

Cerebral Phaeohyphomycosis Caused by Cladosporium spp. in Two Domestic Shorthair Cats

Christopher L. Mariani, DVM, Diplomate ACVIM (Neurology), Simon R. Platt, BVM&S, MRCVS, Diplomate ACVIM (Neurology), Timothy J. Scase, BVM&S, MRCVS, PhD, Elizabeth W. Howerth, DVM, PhD, Diplomate ACVP, Cheryl L. Chrisman, DVM, MS, EdS, Diplomate ACVIM (Neurology) and Roger M. Clemmons, DVM, PhD

From the Departments of Small Animal Clinical Sciences (Mariani, Chrisman, Clemmons) and Pathobiology (Scase), College of Veterinary Medicine, Health Science Center, University of Florida, P.O. Box 100126, Gainesville, Florida 32610-0126 and the Departments of Small Animal Medicine (Platt) and Pathology (Howerth), College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602-7390.

Two domestic shorthair cats presented for clinical signs related to multifocal central nervous system dysfunction. Both cats had signs of vestibular system involvement and anisocoria, and one had generalized seizure activity. Cerebrospinal fluid analysis revealed a neutrophilic pleocytosis with protein elevation in one cat and pyogranulomatous inflammation in the second. Electroencephalography and brain-stem auditory-evoked potentials in the first cat confirmed cerebral cortical and brain-stem involvement. Euthanasia was performed in both cats, and postmortem diagnoses of phaeohyphomycosis secondary to Cladosporium spp. were made based on histopathology and fungal culture in both cats.




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