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Journal of the American Animal Hospital Association 38:235-238 (2002)
© 2002 American Animal Hospital Association

Case Report

Familial Insulin-Dependent Diabetes Mellitus in Samoyed Dogs

Susan E. Kimmel, DVM, Diplomate ACVIM, Cynthia R. Ward, VMD, PhD, Diplomate ACVIM, Paula S. Henthorn, PhD and Rebecka S. Hess, DVM, Diplomate ACVIM

From the Sections of Medicine (Kimmel, Ward, Hess) and Medical Genetics (Henthorn), Department of Clinical Studies, Veterinary Hospital of the University of Pennsylvania, 3900 Delancey Street, Philadelphia, Pennsylvania 19104.

Address all correspondence to Dr. Kimmel.

Five adult Samoyed dogs from two unrelated litters were diagnosed with diabetes mellitus. Two full-sibling male dogs (Family A) were raised in the same household. The other three dogs, two female and one male, were also full siblings (Family B) raised in different households. All five dogs developed polyuria and polydipsia and demonstrated fasting hyperglycemia and glucosuria. Diabetes mellitus was diagnosed in all five dogs and responded to appropriate therapy with insulin. The occurrence of insulin-dependent diabetes mellitus in multiple, closely related Samoyed dogs suggests a familial predisposition in this breed.




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Copyright © 2002 by the American Animal Hospital Association.