Journal of the American Animal Hospital Association 38:246-254 (2002)
© 2002 American Animal Hospital Association
S-Adenosyl-L-Methionine (SAMe) for the Treatment of Acetaminophen Toxicity in a Dog
Kevin P. Wallace, DVM,
Sharon A. Center, DVM, Diplomate ACVIM,
Fiona H. Hickford, BVSc, MVSc, Diplomate ACVIM,
Karen L. Warner, LVT and
Scott Smith, DVM
From the Department of Clinical Sciences, New York State College of Veterinary Medicine, P.O. Box 25, Cornell University, Ithaca, New York 14853–6401.
An 8-month-old, spayed female Shetland sheepdog presented 48 hours after ingesting acetaminophen (1 gm/kg body weight). On presentation, the dog was laterally recumbent and hypovolemic. The dog had brown mucous membranes, severe Heinz-body hemolytic anemia, bleeding tendencies, and a red blood cell (RBC) glutathione (GSH) concentration that was 10% of reference values, despite a regenerative erythroid response. Treatment with s-adenosyl-l-methionine (SAMe) as a GSH donor successfully rescued this dog, despite the animal’s late presentation after drug ingestion. A loading dose (40 mg/kg body weight) of a stable SAMe salt per os was followed by a maintenance dose (20 mg/kg body weight) sid for 7 days. Additional therapeutic interventions included an intravenous (IV) infusion of one unit of packed RBCs (on admission), IV fluid support (3 days), and famotidine (7 days) to reduce gastric acidity. Sequential assessment of RBC GSH concentrations and RBC morphology documented response to antidote administration within 72 hours. This case suggests that SAMe may provide a therapeutic option for treatment of acetaminophen toxicosis in dogs capable of retaining an orally administered antidote and maintaining adequate hepatic function for metabolism of SAMe to its thiol substrates.
Copyright © 2002 by the American Animal Hospital Association.
