JAAHA Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fox, D. B.
Right arrow Articles by Henry, C. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fox, D. B.
Right arrow Articles by Henry, C. J.
Journal of the American Animal Hospital Association 38:347-355 (2002)
© 2002 American Animal Hospital Association

Retrospective Study

Canine Synovial Sarcoma: A Retrospective Assessment of Described Prognostic Criteria in 16 Cases (1994–1999)

Derek B. Fox, DVM, James L. Cook, DVM, PhD, Diplomate ACVS, John M. Kreeger, DVM, PhD, Diplomate ACVP, Marilyn Beissenherz, BS, HT (ASCP) and Carolyn J. Henry, DVM, MS, Diplomate ACVIM (Oncology)

From the Comparative Orthopaedic Laboratory (Fox, Cook, Kreeger), the Veterinary Medical Diagnostic Laboratory of the Department of Pathobiology (Beissenherz), and the Department of Veterinary Medicine and Surgery (Henry), College of Veterinary Medicine, University of Missouri-Columbia, 379 East Campus Drive, Columbia, Missouri 65211.

Address all correspondence to Dr. Fox.

Pertinent patient data and biopsied tissue from 16 cases of canine synovial sarcoma (SS) were reviewed. Histopathological grade, clinical stage, and tissue immunoreactivity to cytokeratin (broad stain, AE1/AE3 and cytokeratin 7) and vimentin were determined and correlated with survival. Effect of treatment on survival was similarly evaluated. Neither clinical stage nor histopathological grade significantly affected survival patterns. Tissues from all cases stained >30% positively with vimentin, whereas no tissue from any case exhibited cytokeratin immunoreactivity. Dogs receiving surgical tumor excision or amputation had a significantly higher survivability than those receiving no treatment (P<0.02). Treatment aggressiveness may be more appropriate than clinical staging or tumor grading in predicting survival. Reliability of diagnosing and prognosticating canine SS with current immunohistochemistry protocols should be questioned.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Animal Hospital Association.