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Hematological Toxicity and Therapeutic Efficacy of Lomustine in 20 Tumor-Bearing Cats: Critical Assessment of a Practical Dosing Regimen

From the Department of Veterinary Medicine (Fan, Kitchell, Jones, Hintermeister, Paria), Veterinary Medical Teaching Hospital, University of Illinois, 1008 West Hazelwood Drive, Urbana, Illinois 61802-4714 and the All-Care Animal Referral Center (Dhaliwal), 18440 Amistad Street, Fountain Valley, California 92708.

Address all correspondence to Dr. Fan.

Twenty cats with spontaneously arising tumors received oral lomustine at a dose range of 32 to 59 mg/m² every 21 days. Due to biohazard concerns associated with lomustine capsule reformulation, a standardized 10-mg capsule dosage was used for all cats regardless of body weight. Severe hematological toxicity was infrequent, with the incidence of either grade III or IV neutropenia and thrombocytopenia being 4.1% and 1.0%, respectively. Cats receiving higher cumulative doses of lomustine trended toward a greater likelihood for progressive neutropenia (P=0.07). Two cats with lymphoma, two cats with fibrosarcoma, and one cat with multiple myeloma achieved a measurable partial response to lomustine therapy. Cats treated with higher dosages of lomustine trended toward statistically significant higher response rates (P=0.07).

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