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Journal of the American Animal Hospital Association 38:507-514 (2002)
© 2002 American Animal Hospital Association

Original Article

Comparison of the Effects of Buprenorphine, Oxymorphone Hydrochloride, and Ketoprofen for Postoperative Analgesia After Onychectomy or Onychectomy and Sterilization in Cats

Stephanie Dobbins, DVM, Nancy O. Brown, VMD, MA, Diplomate ACVS, Diplomate ACVIM and Frances S. Shofer, PhD

From the Pennsylvania Veterinary Specialty and Emergency Associates, Hickory Veterinary Hospital (Dobbins, Brown), 2303 Hickory Road, Plymouth Meeting, Pennsylvania 19462 and the Department of Emergency Medicine (Shofer), School of Medicine, the University of Pennsylvania, 3900 Spruce Street, Philadelphia, Pennsylvania 19104.

In this prospective, randomized, blinded study, 68 clinically healthy cats that had onychectomy (n=20), onychectomy and castration (n=20), or onychectomy and ovariohysterectomy (n=28) were randomly assigned to one of four postoperative analgesic treatment groups: buprenorphine (0.01 mg/kg body weight, intramuscularly [IM]), oxymorphone hydrochloride (0.05 mg/kg body weight, IM), ketoprofen (2 mg/kg body weight, IM), and placebo (physiological saline). Sedation scores, visual analog pain scores, cumulative pain scores, serum cortisol concentration, and appetite were used to assess postoperative analgesic effect. Buprenorphine demonstrated the highest efficacy with the lowest cumulative pain scores and serum cortisol levels.




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G. L. Carroll and S. M. Simonson
Recent Developments in Nonsteroidal Antiinflammatory Drugs in Cats
J. Am. Anim. Hosp. Assoc., November 1, 2005; 41(6): 347 - 354.
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