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Protein-Losing Enteropathy Associated With Cystic Mucoid Changes in the Intestinal Crypts of Two Dogs

From the Departments of Small Animal Medicine and Surgery (Willard) and Pathobiology (Mansell), College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843 and the Department of Medicine (Zenger), University of California, San Francisco, California 94110.

Address all correspondence to Dr. Willard.

Two dogs were emaciated and hypoalbuminemic due to protein-losing enteropathy associated with a severe, focal, mucoid, cryptal ectasia of the duodenum and marked villus atrophy. In one case, diseased portions of the duodenum were obvious endoscopically and were limited to discrete, focal areas in the small intestine, with apparently more undiseased tissue than diseased tissue being present. The signs and lesions in one dog resolved after initiating combination dietary and pharmacological therapy.