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Effect of Anticonvulsant Dosages of Potassium Bromide on Thyroid Function and Morphology in Dogs

From the Department of Clinical Sciences (Paull, Scott-Moncrieff, DeNicola), Center for the Human-Animal Bond (N. Glickman), and Department of Veterinary Pathobiology (L. Glickman), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907-1248 and the Endocrine Section (Refsal), Animal Health Diagnostic Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan 48824-1316.

A placebo-controlled experiment was performed to evaluate the effect of potassium bromide on the canine thyroid gland. Basal total thyroxine, free thyroxine, and basal thyrotropin serum concentrations were evaluated over a 6-month period in potassium bromide-treated and control dogs. A thyrotropin-releasing hormone stimulation test was also performed in all dogs at the beginning and conclusion of the study. Thyroid histopathology was compared between treated and control dogs at the end of the study. No difference was detected in any parameter between the two groups at the end of the study. A decline in thyroid hormone concentrations over the course of the study did occur in both groups of dogs. Potassium bromide does not appear to have a significant effect on canine thyroid function or morphology.