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Evaluation of Systemic and Secretory IgA Concentrations and Immunohistochemical Stains for IgA-Containing B Cells in Mucosal Tissues of an Irish Setter With Selective IgA Deficiency

From the Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616.

Immunoglobulin A is the predominant secretory antibody at mucosal surfaces. In the dog, immunoglobulin A deficiency (IgAD) is characterized by low to absent serum IgA and normal to elevated serum immunoglobulin G (IgG) and immunoglobulin M (IgM) concentrations. However, studies comparing serum and secretory IgA in dogs have often documented a poor correlation, suggesting that serum concentrations should not be used to estimate mucosal secretion of this antibody. This report demonstrates the concurrent use of serum IgA, IgG, and IgM; secretory IgA (from bronchoalveolar lavage fluid); and immunohistochemical stains on bronchial and duodenal mucosa for IgA-containing B cells in a young Irish setter with recurrent respiratory and gastrointestinal signs.

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				E. A. Flickinger, C. M. Grieshop, N. R. Merchen, and G. C. Fahey Jr. Immunoglobulin A Concentrations in Adult Dogs Vary According to Sample Type and Collection Time and Method J. Nutr., August 1, 2004; 134(8): 2130S - 2132S. [Full Text] [PDF]