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Chlorambucil-Induced Myoclonus in a Cat With Lymphoma

From the Department of Veterinary Clinical Medicine (Benitah, de Lorimier, Kitchell), Veterinary Teaching Hospital, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, Urbana, Illinois 61802 and The Cat Clinic (Gaspar), 19850 Kedzie Avenue, Flossmor, Illinois 60422.

Address all reprint requests to Dr. Kitchell.

Chlorambucil is an alkylating agent commonly used in veterinary oncology for conditions including lymphoma. Chlorambucil neurotoxicity has been well recognized in human patients. Onsets of central nervous system signs, such as myoclonus, tremors, muscular twitching, agitation, and tonic-clonic seizures, have been reported in humans and laboratory animals treated with chlorambucil. This case of a cat with intestinal lymphoma represents the first veterinary patient reported to have chlorambucil-induced neurotoxicity. Neurotoxicity should be considered a potential side effect of chlorambucil therapy in veterinary patients.