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Large Granular Lymphocytosis, Lymphocyte Subset Inversion, Thrombocytopenia, Dysproteinemia, and Positive Ehrlichia Serology in a Dog

From the Departments of Clinical Sciences (Heeb, Chun) and Diagnostic Medicine and Pathobiology (Wilkerson, Ganta), Kansas State University, 106A Mosier Hall, 1800 Denison Avenue, Manhattan, Kansas 66506.

A 7-year-old, mixed-breed dog was presented for evaluation of a possible lymphocytic leukemia. Results of laboratory testing included thrombocytopenia, large granular lymphocytosis, inverted CD4:CD8 ratio, hyperglobulinemia, and hypoalbuminemia. Results of a tick-borne disease panel indicated a positive immunoglobulin G serum titer (1:2,048) to Ehrlichia canis, supporting exposure to this organism. The dog responded to a combination treatment of doxycycline and prednisone. A review of the literature and novel diagnostic methods that aided in the diagnosis of this case are discussed.

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