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Journal of the American Animal Hospital Association 39:558-562 (2003)
© 2003 American Animal Hospital Association

Original Article

Clindamycin in the Treatment of Babesia gibsoni Infections in Dogs

Retno Wulansari, DVM, Agus Wijaya, PhD, Hitoshi Ano, PhD, Yoichiro Horii, PhD, Tetsuo Nasu, PhD, Shin-ichi Yamane, BS and Susumu Makimura, DVM, PhD

From the Laboratory of Veterinary Internal Medicine (Wulansari, Wijaya, Ano, Horii, Makimura); the Laboratory of Veterinary Anatomy (Nasu); Division of Fisheries (Yamane), Faculty of Agriculture; Miyazaki University, Miyazaki-shi, 889-2192, Japan.

Address all correspondence to Dr. Makimura.

This report examines the effectiveness of clindamycin for the treatment of babesiosis in dogs (n=10) experimentally infected with Babesia gibsoni (B. gibsoni). Clindamycin (25 mg/kg body weight, per os, q 12 hours for 14 days) gradually reduced parasitemia levels and induced morphological changes that indicated degeneration of parasites (e.g., segmentation; size reduction; localization in the cell limbic and/or torn state of the nucleus; and swelling, decrease, or disappearance of the cytoplasm) in the majority of dogs. Clindamycin treatment reduced the clinical symptoms characteristic of Babesia infection, including anemia, anorexia, and listlessness. Clindamycin might be useful as a medicine for treatment of B. gibsoni infection.




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