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Vinblastine and Prednisolone as Adjunctive Therapy for Canine Cutaneous Mast Cell Tumors

From the Division of Veterinary and Biomedical Sciences (Davies, Wyatt, Robertson, Irwin), Murdoch University, South Street, Murdoch 6150, Western Australia, Australia; and Vetpath Laboratory Services (Jardine), P.O. Box 18, Belmont 6984, Western Australia, Australia.

Twenty-seven dogs with inadequately excised, cutaneous mast cell tumors (MCT; 20 residual microscopic disease, seven marginal excision) were treated with a vinblastine and prednisolone chemotherapeutic protocol. Twenty dogs were available for follow-up examination after 12 months. One dog suffered local recurrence of the tumor, four dogs developed new cutaneous tumors, and one dog had both events. Fourteen dogs were free of MCT. There was no confirmed tumor-related mortality. Although toxicity from the chemotherapy was generally mild, one dog died of sepsis during treatment.