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Repetitive Propofol Administration in Dogs and Cats

From the Departments of Small Animal Medicine and Surgery (Matthews, Brown) and Large Animal Medicine and Surgery (Barling), Texas A & M University, College Station, Texas 77843-4474; Texas Veterinary Medical Diagnostic Laboratory (Lovering), College Station, Texas 77843; and Schering Plough Animal Health (Herrig), Union, New Jersey 07083-1982.

A bolus of propofol was administered to 10 dogs (6 mg/kg intravenously [IV]) and 10 cats (10 mg/kg IV) on three consecutive days. The occurrence of apnea, heart and respiratory rates, blood pressure, time to movement, and changes in a complete blood count and biochemical profile were recorded. Apnea was not seen in the dogs but was seen in three cats. Slight increases in the number of Heinz bodies were seen in six cats, but the increases were not considered clinically significant. No apparent cumulative adverse effects were seen from a bolus of bisulfite-containing propofol, administered on three consecutive days.