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Journal of the American Animal Hospital Association 40:285-291 (2004)
© 2004 American Animal Hospital Association

Original Article

Zonisamide Therapy for Refractory Idiopathic Epilepsy in Dogs

Curtis W. Dewey, DVM, MS, Diplomate ACVIM (Neurology), Diplomate ACVS, Rose Guiliano, LVT, Dawn M. Boothe, DVM, PhD, Diplomate ACVIM, Diplomate ACVCP, Jason M. Berg, DVM, Diplomate ACVIM (Neurology, Internal Medicine), Gregg D. Kortz, DVM, Diplomate ACVIM (Neurology), Richard J. Joseph, DVM, Diplomate ACVIM (Neurology) and Steven C. Budsberg, DVM, MS, Diplomate ACVS

From the Department of Surgery (Dewey, Guiliano), Long Island Veterinary Specialists, 163 South Service Road, Plainview, New York 11803; the Department of Physiology and Pharmacology (Boothe), College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843-4474; County Animal Specialty Group (Berg, Joseph), 1574 Central Avenue, Yonkers, New York 10710; California Veterinary Neurology and Neurosurgery Specialists (Kortz), 1100 Atlantic Street, Roseville, California 95678; and the Department of Small Animal Medicine and Surgery (Budsberg), College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602.

Twelve dogs with poorly controlled idiopathic epilepsy were entered into a prospective, open-label, noncomparative study. Oral zonisamide was administered as an additional therapy at a dosage adequate to achieve serum drug concentrations of 10 to 40 µg/mL. Seizure frequency before and after initiation of zonisamide therapy was recorded. A dosing interval of q 12 hours was sufficient to maintain serum zonisamide concentrations within the therapeutic range. The mean dosage of zonisamide required was 8.9 mg/kg q 12 hours. Seven (58%) dogs responded favorably, experiencing a mean reduction in seizures of 81.3%. Five dogs had an increase in seizure frequency. Mild side effects (e.g., transient sedation, ataxia, vomiting) occurred in six dogs.






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