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Iridium-192 Interstitial Brachytherapy as Adjunctive Treatment for Canine Cutaneous Mast Cell Tumors

From the Departments of Small Animal Medicine and Surgery (Northrup and Gieger), Anatomy and Radiology (Roberts and Allen), and Pathology (Howerth), Comparative Oncology Program, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602.

Eleven dogs with cutaneous mast cell tumors (MCTs) were treated with surgery and iridium-192 (¹⁹²Ir) interstitial brachytherapy. Minimum tumor doses ranged from 47.2 to 63.3 Gy. Treated tumors were classified as grade II (n=7) or III (n=4). Five dogs had recurrences with a median progression-free interval of 1391 days, and six dogs had no recurrence at a median follow-up time of 942 days. Acute adverse effects were well tolerated, and late effects were mild. One dog developed a second tumor of a different cell type in the radiation treatment field.