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Journal of the American Animal Hospital Association 40:376-384 (2004)
© 2004 American Animal Hospital Association

Original Article

Comparison of Serological Tests for the Detection of Natural Heartworm Infection in Cats

Paul Berdoulay, DVM, Julie K. Levy, DVM, PhD, Diplomate ACVIM (Internal Medicine), Patti S. Snyder, DVM, MS, Diplomate ACVIM (Internal Medicine), Michael J. Pegelow, BS, Jennifer L. Hooks, BS, Larissa M. Tavares, BA, Nicole M. Gibson, PhD and Marc E. Salute, BS

From the Department of Small Animal, Clinical Sciences, (Berdoulay, Levy, Pegelow, Hooks, Tavares, Salute), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610; Jacksonville Veterinary Internal, Medicine and Referral Center (Snyder), Orange Park, Florida 32073; and the Department of Educational Leadership, (Gibson), Valdosta State University, Valdosta, Florida 31698.

Address all correspondence to Dr. Levy.

Serological tests were performed on 380 cats with necropsy-confirmed heartworm status to compare the performance of currently available commercial laboratory and point-of-care heart-worm serological tests in a heartworm-endemic area. Overall, antigen tests detected 79.3% to 86.2% of heartworm infections and were highly specific. Most cats with false-negative antigen tests had a single male worm. Antibody tests detected 62.1% to 72.4% of heartworm infections and had a wider range of false-positive results (1.4% to 19.1%) than antigen tests (0.3% to 2.0%). Serological tests for feline heartworm infection varied in diagnostic performance. Combining results from antigen and antibody tests achieved greater sensitivity than using either test alone.






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Copyright © 2004 by the American Animal Hospital Association.