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Effect of a Single Plasma Transfusion on Thromboembolism in 13 Dogs With Primary Immune-Mediated Hemolytic Anemia

From the Department of Veterinary Clinical Sciences (Thompson, Scott-Moncrieff), School of Veterinary Medicine, Lynn Hall, Purdue University, West Lafayette, Indiana 47907 and the Comparative Coagulation Section (Brooks), Diagnostic Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.

Thirteen dogs with primary immune-mediated hemolytic anemia received fresh-frozen plasma within 12 hours of admission, in addition to unfractionated heparin and other therapies, such as prednisone, azathioprine, and packed red blood cell transfusion. Antithrombin activity was quantified prior to transfusion and at 30 minutes and 48 hours after transfusion. Plasma antithrombin activity did not change significantly after a single plasma transfusion. There were no deaths in the first 48 hours of treatment. Thromboembolism was identified at necropsy in six of 10 dogs that died within 12 months of admission. There was no significant difference in the incidence of thromboembolism between the current treatment group and a historical control group.