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Transdermal Fentanyl Patches in Small Animals

From the Department of Small Animal Medicine and Surgery (Hofmeister), College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602 and the Department of Small Animal Clinical Sciences (Egger), College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996.

Fentanyl citrate is a potent opioid that can be delivered by the transdermal route in cats and dogs. Publications regarding transdermal fentanyl patches were obtained and systematically reviewed. Seven studies in cats and seven studies in dogs met the criteria for inclusion in this review. Dogs achieved effective plasma concentrations approximately 24 hours after patch application. Cats achieved effective plasma concentrations 7 hours after patch application. In dogs, transdermal fentanyl produced analgesia for up to 72 hours, except for the immediate 0- to 6-hour postoperative period. In cats, transdermal fentanyl produced analgesia equivalent to intermittent butorphanol administration for up to 72 hours following patch application.