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Efficacy of Boric-Complexed Zinc and Acetic-Complexed Zinc Otic Preparations for Canine Yeast Otitis Externa

From the Animal Dermatology Clinics, 2965 Edinger Avenue, Tustin, California 92780 and 5610 Kearny Mesa Boulevard, San Diego, California 92111 (Mendelsohn, Griffin, Rosenkrantz, Boord); and the Addison Biological Laboratory, Inc. (Brown), 507 North Cleveland Avenue, Fayette, Missouri 65248.

The purpose of this 2-week, double-blinded, controlled clinical trial was to evaluate the efficacy of topical amino acid-complexed zinc gluconate formulated with boric acid (ZGB) or acetic acid (ZGA) versus a topical placebo in the treatment of yeast otitis externa in dogs. Included in the study were dogs with otitis externa and a cytopathological finding of yeast organisms in the affected ear. Ears were treated with the placebo, ZGA, or ZGB medications. Yeast counts as well as clinical appearance of the ears were monitored. Results revealed that ZGB significantly reduced the number of yeast organisms in cases of otitis externa.