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Journal of the American Animal Hospital Association 41:3-11 (2005)
© 2005 American Animal Hospital Association

Effects of Clomipramine on Cats Presented for Urine Marking

Gary M. Landsberg, BSc, DVM, Diplomate ACVB and Andrea L. Wilson, BSc, DVM

From the Doncaster Animal Clinic, 99 Henderson Avenue, Thornhill, Ontario, Canada L3T 2K9.

Twenty-five cats exhibiting at least four episodes of vertical urine marking per week were assessed. Following a medical workup, a 4-week clomipramine trial was instituted, using a mean dose of 0.54 mg/kg per os q 24 hours. No concurrent behavioral or environmental modifications were applied. There was a statistically significant (P<0.0001) decrease in urine spraying when the cats were on clomipramine, with 20 of 25 cats having a ≥75% reduction in spraying within 4 weeks. Side effects were mild. Twenty cats were followed for an additional 5 months. Fifteen cats required medication to control the spraying, often at a reduced dose.







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