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Myasthenia Gravis and Hypothyroidism in a Dog With Meningomyelitis

From the Department of Small Animal Medicine (Levine, Bergman, Coates), College of Veterinary Medicine, Texas A&M University, College Station, Texas 77843 and The Department of Pathology (Shelton), School of Medicine, University of California, San Diego, La Jolla, California 92093.

A 12-year-old, spayed female miniature poodle was evaluated because of a 4-day history of paraparesis, dysuria, and tenesmus. Neurological assessment suggested peripheral nervous system dysfunction, predominantly pelvic limb weakness with a possible concurrent sixth lumbar (L₆) to second sacral (S₂) myelopathy. Further studies supported the diagnoses of myasthenia gravis, hypothyroidism, and meningomyelitis. To the authors’ knowledge, this is the first reported case of concurrent myasthenia gravis and meningomyelitis in the dog. It was unclear whether the identified conditions evolved from a shared etiopathogenesis or were merely coincidental.