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Journal of the American Animal Hospital Association 41:284-291 (2005)
© 2005 American Animal Hospital Association

Retrospective Study

Taurine-Deficient Dilated Cardiomyopathy in a Family of Golden Retrievers

Marie C. Bélanger, DVM, MS, Diplomate ACVIM, Mathieu Ouellet, DVM, Guillaume Queney, PhD and Maxim Moreau, M.Sc.

From the Companion Animal Research Group (Bélanger, Ouellet, Moreau), Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Montreal, St-Hyacinthe, Quebec, Canada, J2S 7C6 and Antagene (Queney), Immeuble Le Meltem, 2 allée des Séquoias, 69760 Limonest, France.

A reversible taurine-deficient dilated cardiomyopathy occurred in five related golden retrievers. An apical systolic heart murmur was the most common physical abnormality. According to fractional shortening and end-systolic diameter on echocardiography, significant improvements (P<0.005) were recorded within 3 to 6 months of starting taurine supplementation. The dogs regained substantial systolic function, and four were weaned off all cardiac medications except taurine. This response to therapy was unusual, because canine dilated cardiomyopathy is generally progressive and fatal.




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