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Journal of the American Animal Hospital Association 41:413-420 (2005)
© 2005 American Animal Hospital Association

Case Report

Cardiac Toxicity From Phenylpropanolamine Overdose in a Dog

John M. Crandell, DVM, Diplomate ACVIM and Wendy A. Ware, DVM, MS, Diplomate ACVIM (Cardiology)

From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250.

A 5-year-old, 29-kg, female Labrador retriever developed tachypnea, tachycardia, and ataxia following ingestion of approximately 48 mg/kg of phenylpropanolamine. Initial diagnostic tests showed multiform ventricular tachycardia, left ventricular dilatation with a focal dyskinetic region in the dorsal interventricular septum, and elevations in creatinine kinase and cardiac troponin I. All abnormalities resolved within 6 months. The transient electrocardiographic, echocardiographic, and biochemical abnormalities were consistent with myocardial necrosis from infarction or direct catecholamine-induced myocardial toxicity.






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