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Cardiac Toxicity From Phenylpropanolamine Overdose in a Dog

From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011-1250.

A 5-year-old, 29-kg, female Labrador retriever developed tachypnea, tachycardia, and ataxia following ingestion of approximately 48 mg/kg of phenylpropanolamine. Initial diagnostic tests showed multiform ventricular tachycardia, left ventricular dilatation with a focal dyskinetic region in the dorsal interventricular septum, and elevations in creatinine kinase and cardiac troponin I. All abnormalities resolved within 6 months. The transient electrocardiographic, echocardiographic, and biochemical abnormalities were consistent with myocardial necrosis from infarction or direct catecholamine-induced myocardial toxicity.

This article has been cited by other articles:

				M. Kent, C. Reiss, and U. Blas-Machado Elevated Cardiac Troponin I in a Dog With an Intracranial Meningioma and Evidence of Myocardial Necrosis J. Am. Anim. Hosp. Assoc., January 1, 2010; 46(1): 48 - 55. [Abstract] [Full Text] [PDF]