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Effects of Intravenous Diazepam or Microdose Medetomidine on Propofol-Induced Sedation in Dogs

From the Department of Veterinary Clinical Sciences (Ko, White, Galloway, Inoue), Center for Veterinary Health Sciences, and the Department of Statistics (Payton), College of Arts and Sciences, Oklahoma State University, Stillwater, Oklahoma 74078.

This crossover study tested the hypothesis that both diazepam and microdose medetomidine would comparably reduce the amount of propofol required to induce sedation. Four different medications, namely high-dose diazepam (0.4 mg/kg intravenously [IV]), low-dose diazepam (0.2 mg/kg IV), medetomidine (1 µg/kg IV), and placebo (0.5 mL physiological saline IV) were followed by propofol (8 mg/kg IV) titrated to a point where intubation could be performed. The effects of medetomidine were comparable to the effects of high-dose diazepam and significantly better than the effects of low-dose diazepam or placebo. Dogs in all treatment groups had transient hypoxemia, and induction and recovery qualities were similar.

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