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Spontaneous Lymphoma in a Prairie Dog (Cynomys ludovicianus)

From the Departments of Veterinary Emergency Medicine (Miwa, Matsunaga, Ogawa), Veterinary Pathology (Nakayama, Kurosawa), and Veterinary Surgery (Sasaki), Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657.

Address all correspondence to Dr. Sasaki.

A 4-year-old, female, black-tailed prairie dog (Cynomys ludovicianus) was examined for acute dyspnea and two skin masses. Tentative diagnosis of lymphoma was made based on cytology of pleural effusion and the skin masses. Administration of prednisolone was initially effective in improving the condition; however, the clinical signs deteriorated after radiation therapy and administration of cyclophosphamide. Postmortem examination revealed that neoplastic lymphocytes had infiltrated most of the organs, and the histopathological diagnosis was multi-centric lymphoma.