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Journal of the American Animal Hospital Association 42:178-188 (2006)
© 2006 American Animal Hospital Association

Efficacy and Safety of Preoperative Etodolac and Butorphanol Administration in Dogs Undergoing Ovariohysterectomy

Tomohito Inoue, DVM, Jeff C. Ko, DVM, MS, Diplomate ACVA, Ronald E. Mandsager, DVM, Diplomate ACVA, Mark E. Payton, PhD, David S. Galloway, DVM, MS and Douglas N. Lange, DVM, Diplomate ACVS

From the Department of Veterinary Clinical Sciences (Inoue), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907 the Department of Veterinary Clinical Sciences (Mandsager), Veterinary Medical Center, St. Paul, Minnesota 55108-1016; the Department of Statistics (Payton), College of Arts and Sciences, Oklahoma State University, Stillwater, Oklahoma 74078; the Department of Veterinary Clinical Sciences (Ko, Galloway), Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74078; and Southwest Veterinary Surgical (Lange), 7807 North 35th Avenue, Phoenix, Arizona 85051.

Eighteen dogs undergoing ovariohysterectomy were premedicated with etodolac, butorphanol, or their combination. Various parameters, such as blood pressure, isoflurane requirements, behavioral pain scores, plasma cortisol concentration, plasma glucose concentration, and mucosal bleeding time, were assessed. The integrated plasma cortisol values were significantly lower in the etodolac and etodolac with butorphanol groups. Dogs receiving etodolac and butorphanol had the lowest behavioral pain scores from extubation until the end of monitoring. Isoflurane concentration over time (area under the curve), buccal mucosal bleeding time, and indices of renal function were not significantly different among the treatment groups.






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