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Pemphigus Foliaceus in 91 Dogs

From the Department of Clinical Sciences (Mueller, Krebs, Fieseler), College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523 and Dermatology for Animals (Power), 106 East Campbell Avenue, Campbell, California 95008.

A retrospective study of 91 dogs with pemphigus foliaceus was performed. Clinical signs of the disease included crusts (n=79), pustules (n=36), and alopecia (n=33). Lesions were most common on the trunk (n=53), inner pinnae (n=46), face (n=37), and foot pads (n=32). Cytological evaluation revealed acantholytic keratinocytes in 37 of 48 dogs. Results of combination treatment with prednisolone and azathioprine were comparable to results with prednisolone therapy alone. More than half of the dogs achieved remission with appropriate therapy, and another 25% significantly improved.

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