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Journal of the American Animal Hospital Association 42:298-301 (2006)
© 2006 American Animal Hospital Association

Case Report

Acute Hepatopathy Associated With Mitotane Administration in a Dog

Craig B. Webb, PhD, DVM, Diplomate ACVIM and David C. Twedt, DVM, Diplomate ACVIM

From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, Colorado 80523.

An adult dog with a persistent elevation in alkaline phosphatase enzyme activity was started on mitotane for suspected hyperadrenocorticism. One month later, the dog was presented for intermittent anorexia and acute icterus. The dog’s liver enzyme activities and total bilirubin were markedly elevated, prothrombin time was prolonged, and blood urea nitrogen and glucose were low. Histopathology revealed marked, centrilobular, hepatocellular loss. After discontinuation of the mitotane, the dog recovered with supportive care and was normal 3 months later, which was consistent with mitotane-associated hepatic failure.






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Copyright © 2006 by the American Animal Hospital Association.