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Journal of the American Animal Hospital Association 42:336-343 (2006)
© 2006 American Animal Hospital Association

The Effects of Clomipramine Hydrochloride in Cats With Psychogenic Alopecia: A Prospective Study

Petra A. Mertens, DVM, PhD, Diplomate ECVBM, Diplomate ACVB, Sheila Torres, DVM, PhD, Diplomate ACVD and Carl Jessen, DVM, PhD

From the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55108.

A double-blind, placebo-controlled clinical trial was conducted to determine the efficacy of clomipramine hydrochloride in cats with psychogenic alopecia. Twenty-five cats were randomly assigned to receive clomipramine hydrochloride (0.5 mg/kg orally q 24 hours) or placebo for 56 days. Eleven cats in each group completed the trial. The results of this study showed that clomipramine hydrochloride failed to demonstrate significant changes in the number of grooming bouts, hair regrowth, and the area of alopecia in cats with psychogenic alopecia when compared to a placebo. It was uncertain whether these results reflected a lack of drug efficacy, insufficient treatment duration, or an insufficient number of cases enrolled.







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