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Journal of the American Animal Hospital Association 42:430-434 (2006)
© 2006 American Animal Hospital Association

Retrospective Study

Radiation Therapy for Incompletely Excised Grade II Canine Mast Cell Tumors

Valerie Jasmine Poirier, DMV, Diplomate ACVIM (Oncology), William M. Adams, DVM, Diplomate ACVR, Lisa J. Forrest, VMD, Diplomate ACVR, Eric M. Green, DVM, Diplomate ACVR, Richard R. Dubielzig, DVM, Diplomate ACVP and David M. Vail, DVM, MS, Diplomate ACVIM (Oncology)

From the Department of Diagnostic Imaging and Radiation Oncology (Poirier), Vetsuisse Faculty, University of Zurich, Wintherthurerstrasse 260, Zurich, 8057 Switzerland; the Departments of Medical Sciences (Poirier, Vail), Surgical Sciences (Adams, Forrest, Green), and Pathobiological Sciences (Dubielzig), School of Veterinary Medicine, University of Wisconsin-Madison; and the Comprehensive Cancer Center (Forrest, Vail) and MacEwen Center for Clinical Trials and Translational Research (Vail), University of Wisconsin-Madison, Madison, Wisconsin 53706.

Forty-five dogs with incompletely excised grade II mast cell tumors were treated with radiation using a cobalt 60 teletherapy unit (15 fractions of 3.2 Gy for a total of 48 Gy). Twenty-four of the dogs underwent prophylactic regional lymph node irradiation. Three (6.7%) dogs had tumor recurrence, two (4.4%) dogs developed metastasis, and 14 (31%) dogs developed a second cutaneous mast cell tumor. No difference in overall survival rate was observed between the dogs receiving and not receiving prophylactic irradiation of the regional lymph node.




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K. Hosoya, W. C. Kisseberth, F. J. Alvarez, A. Lara-Garcia, G. Beamer, P. C. Stromberg, and C. G. Couto
Adjuvant CCNU (Lomustine) and Prednisone Chemotherapy for Dogs With Incompletely Excised Grade 2 Mast Cell Tumors
J. Am. Anim. Hosp. Assoc., January 1, 2009; 45(1): 14 - 18.
[Abstract] [Full Text] [PDF]


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