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Journal of the American Animal Hospital Association 43:21-26 (2007)
© 2007 American Animal Hospital Association

Evaluation of Azathioprine on Lesion Severity and Lymphocyte Blastogenesis in Dogs With Perianal Fistulas

Kenneth R. Harkin, DVM, Diplomate ACVIM, Dianne Phillips, DVM, Diplomate ACVIM and Melinda Wilkerson, DVM, PhD, Diplomate ACVP

From the Departments of Clinical Sciences (Harkin, Phillips) and Diagnostic Medicine/Pathobiology (Wilkerson), College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506.

Fourteen dogs with perianal fistulas were entered into a prospective clinical study to investigate the effects of long-term azathioprine on clinical outcome and to determine if the clinical results correlated with lymphocyte blastogenesis tests. Complete remission of perianal fistulas was seen in eight (57%) of 14 dogs; partial remission occurred in one (7%) dog; and no response was detected in five (36%) dogs. The results of lymphocyte blastogenesis assays did not correlate with therapeutic response.






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Copyright © 2007 by the American Animal Hospital Association.