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Journal of the American Animal Hospital Association 43:27-32 (2007)
© 2007 American Animal Hospital Association

Phase II Clinical Trial of Combination Chemotherapy With Dexamethasone for Lymphoma in Dogs

Chelsea B. Greenberg, DVM, MS, Pedro A. Boria, DVM, MS, Diplomate ACVIM (Oncology), Antonella Borgatti-Jeffreys, DVM, MS, Rose E. Raskin, DVM, PhD, Diplomate ACVP and Michael D. Lucroy, DVM, MS, Diplomate ACVIM (Oncology)

From the Departments of Veterinary Clinical Sciences, (Greenberg, Boria, Borgatti-Jeffreys, Lucroy) and Veterinary Pathobiology (Raskin), Purdue University, 625 Harrison Street, West Lafayette, Indiana 47907.

Address all correspondence to Dr. Lucroy.

Dogs with histologically confirmed lymphoma were treated with a 14-week induction chemotherapy protocol that included dexamethasone. A phase II clinical trial was done using a standard two-stage design. Complete remission occurred in 21 (88%) dogs, with a median initial progression-free interval of 186 days. Toxicity was mild and self-limiting in the majority of dogs.






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Copyright © 2007 by the American Animal Hospital Association.