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Journal of the American Animal Hospital Association 43:149-156 (2007)
© 2007 American Animal Hospital Association

Treatment of Feline Hypertension With Transdermal Amlodipine: A Pilot Study

Scott Roderick Helms, DVM, Diplomate ABVP

From the Unifour Veterinary Referrals, 126 Highway 321 Southwest, Hickory, North Carolina 28602.

This prospective study evaluated transdermal amlodipine for the control of hypertension in six cats. Cats were treated with oral amlodipine until blood pressures decreased to <180 mm Hg. They were maintained on this dose for 7 days and then administered identical doses of transdermal amlodipine for 7 days. Oral amlodipine decreased pressure by a median of 73 mm Hg, which subsequently increased by 20 mm Hg after 7 days of transdermal amlodipine. Plasma concentrations of amlodipine were measured after oral and transdermal dosing. Additional studies are needed to determine dosing, pharmacokinetics, and efficacy.






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Copyright © 2007 by the American Animal Hospital Association.