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Refractory Seizures Associated With an Organic Aciduria in a Dog

From the Department of Small Animal Medicine (Platt), College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602-7390; Veterinary Internal Medicine and Critical Care Referrals (McGrotty), Broadleys Veterinary Hospital, Craig Leith Road, Broadleys, Stirling, FK7 7LE, Scotland; the Department of Veterinary Clinical Sciences (Abramson), Veterinary Hospital, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210; and the Departments of Clinical Chemistry and Pediatrics (Jakobs), Vrije Universiteit Medical Centre, De Boelelaan 1117 1081 HV, Amsterdam, The Netherlands.

A 6-month-old, female Cavalier King Charles spaniel exhibited seizures that were difficult to control with standard anticonvulsants over a 12-month period. The diagnosis of an organic aciduria with excessive excretion of hexanoylglycine was determined when the dog was 20 months old. Recurrent and cluster seizures were eventually controlled with the addition of levetiracetam to potassium bromide and phenobarbital.