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Plasma Concentrations of Lidocaine in Dogs Following Lidocaine Patch Application

From the Department of Veterinary Clinical Sciences (Ko, Weil), School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907; and the Departments of Veterinary Clinical Sciences (Kitao, Haydon) and Physiological Sciences (Maxwell), Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, Oklahoma 74078.

Transdermal absorption of lidocaine was determined by measuring plasma lidocaine concentrations following skin application of 5% lidocaine patches. Two lidocaine patches were placed on the ventral abdominal midline of seven dogs for 72 hours. Lidocaine was detectable in plasma 12 hours after patch application, and it reached steady-state concentrations between 24 and 48 hours. Plasma lidocaine levels decreased dramatically at 60 hours post-application. Low plasma lidocaine concentrations remained for 6 hours after patch removal. No clinically significant side effects were noted.