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Journal of the American Animal Hospital Association 43:307-312 (2007)
© 2007 American Animal Hospital Association

Antimicrobial Testing of Selected Fluoroquinolones Against Pseudomonas aeruginosa Isolated From Canine Otitis

Lindsay McKay, DVM, Diplomate ACVD, Crystal D. Schuman Rose, BS, Jennifer L. Matousek, DVM, MS, Diplomate ACVD, Lynn S. Schmeitzel, DVM, Diplomate ACVD, Nicole M. Gibson, PhD and Jack M. Gaskin, DVM, PhD, Diplomate ACVM (Microbiology)

From the Department of Dermatology (McKay, Matousek), VCA-Aurora Animal Hospital, 2600 West Galena Boulevard, Aurora, Illinois 60506; the Department of Infectious Disease and Pathology (Schuman Rose, Gaskin), College of Veterinary Medicine, University of Florida, Gainesville, Florida 32610; the Department of Dermatology (Schmeitzel), VCA-Berwyn Animal Hospital, 2845 South Harlem Avenue, Berwyn, Illinois 60305; and Valdosta State University (Gibson), 1500 North Patterson Street, Valdosta, Georgia 31698.

A total of 100 Pseudomonas aeruginosa (P. aeruginosa) isolates were collected over a 1.5- year period from cases of canine otitis. Sensitivities to enrofloxacin, marbofloxacin, and orbifloxacin were determined using minimum inhibitory concentration testing (MICT). Isolates were also tested for sensitivities to enrofloxacin and marbofloxacin using disk-diffusion susceptibility testing (DDST). Isolates were significantly more sensitive to marbofloxacin than to enrofloxacin (z = –4.57; P<0.05) or orbifloxacin (z = –5.02; P<0.05). Agreement was 87% between MICT and DDST for marbofloxacin, with approximately equal numbers of overestimation and underestimation errors. Agreement was 74% between MICT and DDST for enrofloxacin, but DDST tended to overestimate the number of enrofloxacin-susceptible strains. These results suggest that marbofloxacin is more effective against P. aeruginosa than either enrofloxacin or orbifloxacin and that relying on DDST may lead to ineffective enrofloxacin treatment.






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