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Susceptibility of Pseudomonas Isolates From the Ears and Skin of Dogs to Enrofloxacin, Marbofloxacin, and Ciprofloxacin

From the Animal Dermatology Clinic (Wildermuth, Griffin, Boord), 5610 Kearny Mesa Road, Suite B1, San Diego, California 92111 and the Animal Dermatology Clinic (Rosenkrantz), 2965 Edinger Avenue, Tustin, California 92780.

The purpose of this study was to compare susceptibilities of ear and skin Pseudomonas spp. isolates to enrofloxacin, marbofloxacin, and ciprofloxacin. Specimens were obtained from dogs examined in a veterinary dermatology referral hospital. Susceptibilities of ear isolates to enrofloxacin, marbofloxacin, and ciprofloxacin were 46.9%, 66.7%, and 75.0%, respectively. Susceptibilities of skin isolates to the same drugs were 76.2%, 81.0%, and 80.0%, respectively. Ear isolates were significantly less susceptible to enrofloxacin than to ciprofloxacin (P=0.021), and ear isolates were significantly less susceptible to enrofloxacin than were skin isolates (P=0.034). When fluoroquinolone resistance was present, ear isolates were significantly less susceptible to enrofloxacin than to ciprofloxacin (P<0.001) and marbofloxacin (P=0.014).