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Effects of Carprofen and Morphine on the Minimum Alveolar Concentration of Isoflurane in Dogs

From the Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907.

The minimum alveolar concentration (MAC) of isoflurane in dogs was determined following carprofen (2.2 mg/kg per os) alone, morphine (1 mg/kg intravenously) alone, carprofen and morphine, and no drug control in eight healthy adult dogs. Isoflurane MAC following administration of morphine alone (0.81%±0.18%) or carprofen and morphine (0.68%±0.31%) was significantly less than the control MAC (1.24%±0.15%). Isoflurane MAC after carprofen alone (1.13%±0.13%) was not significantly different from the control value. Results indicated that administration of morphine alone or in combination with carprofen significantly reduced the MAC of isoflurane in dogs. The isoflurane MAC reduction was additive between the effects of carprofen and morphine.