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An Expedited Palliative Radiation Protocol for Lytic or Proliferative Lesions of Appendicular Bone in Dogs

From the Department of Clinical Sciences (Knapp-Hoch), College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 and the Department of Veterinary Clinical Sciences (Fidel, Sellon, Gavin), College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610.

Address all correspondence to Dr. Fidel.

Fifty-eight dogs with lytic or proliferative bone lesions were treated with a radiation protocol of two 8-Gy fractions over 2 consecutive days. The protocol was well tolerated, with no increase in early or late effects over previously published protocols. Forty-three (91%) of 47 dogs responded positively to radiation, with a median time of 2 days to onset of pain relief. Median duration of pain relief was 67 days (range 12 to 503 days; mean 99±16 days). Median survival time for all dogs was 136 days (mean 179±18 days). Distal radial location was a positive prognostic indicator for survival (P=0.005).