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Journal of the American Animal Hospital Association 45:3-13 (2009)
© 2009 American Animal Hospital Association

Evaluations of Labrador Retrievers With Exercise-Induced Collapse, Including Response to a Standardized Strenuous Exercise Protocol

Susan M. Taylor, DVM, Diplomate ACVIM (Internal Medicine), Cindy L. Shmon, DVM, DVSc, Diplomate ACVS (Surgery), Vicki J. Adams, DVM, MSc, PhD, MRCVS, James R. Mickelson, PhD, Edward (Ned) E. Patterson, DVM, PhD, Diplomate ACVIM (Internal Medicine) and G. Diane Shelton, DVM, PhD, Diplomate ACVIM (Internal Medicine)

From the Department of Small Animal Clinical Sciences (Taylor, Shmon), Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4 Canada; the Centre for Preventive Medicine (Adams), Animal Health Trust, Lanwades Park, Kentford, Suffolk, United Kingdom CB87UU; the Departments of Biomedical Sciences (Mickelson) and Veterinary Clinical Sciences (Patterson), College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota 55108; and the Comparative Neuromuscular Laboratory (Shelton), Department of Pathology, School of Medicine, University of California–San Diego, La Jolla, California 92093-0709.

Clinical and metabolic variables were evaluated in 14 Labrador retrievers with exerciseinduced collapse (EIC) before, during, and following completion of a standardized strenuous exercise protocol. Findings were compared with previously reported variables from 14 normal Labrador retrievers that participated in the same protocol. Ten of 14 dogs with EIC developed an abnormal gait during evaluation, and these dogs were significantly more tachycardic and had a more severe respiratory alkalosis after exercise compared to the normal dogs. Muscle biopsy characteristics and sequential lactate and pyruvate concentrations were normal. Genetic testing and linkage analysis excluded malignant hyperthermia as the cause of EIC. Common causes of exercise intolerance were eliminated, but the cause of collapse in EIC was not determined.






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