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Journal of the American Animal Hospital Association 45:33-38 (2009)
© 2009 American Animal Hospital Association

Retrospective Study

Use of Single-Agent Carboplatin as Adjuvant or Neoadjuvant Therapy in Conjunction With Amputation for Appendicular Osteosarcoma in Dogs

Brenda Phillips, DVM, Diplomate ACVIM (Oncology), Barbara E. Powers, DVM, PhD, Diplomate ACVP, William S. Dernell, DVM, MS, Diplomate ACVS, Rod C. Straw, BVSc, Diplomate ACVS, Chand Khanna, DVM, PhD, Diplomate ACVIM (Oncology), Gary S. Hogge, DVM, MS, PhD and David M. Vail, DVM, Diplomate ACVIM (Oncology)

From the Veterinary Specialty Hospital of San Diego (Phillips), 1733 Nautilus Street, La Jolla, California 92037; The Animal Cancer Center (Powers, Dernell), Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80526; Australian Animal Cancer Foundation (Straw), Brisbane Veterinary Specialist Centre, Corner of Keong and Old Northern Roads, Albany Creek, 4035, Queensland, Australia; Comparative Oncology Program (Khanna), Center for Cancer Research, 37 Convent Drive, Room 2144, Building 37, Bethesda, Maryland 20892; GSH Biomedical Consulting (Hogge), 1733 Nautilus Street, La Jolla, California 92037; and the Department of Medical Sciences (Vail), School of Veterinary Medicine and The Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin- Madison, 2015 Linden Drive West, Madison, Wisconsin 53706.

Address all correspondence to Dr. Phillips, Veterinary Specialty Hospital of San Diego, 10435 Sorrento Valley Road, San Diego, California 92121.

Survival following amputation and administration of single-agent carboplatin for treatment of appendicular osteosarcoma (OSA) in dogs was retrospectively examined. Records of 155 dogs with appendicular OSA treated with amputation and single-agent carboplatin were included from 14 centers. Any carboplatin dosage, number of doses, and protocol schedule were eligible for inclusion. The median disease-free interval (DFI) was 256 days. The median overall survival time was 307 days. Similar prognostic survival factors were identified in this study as reported in prior studies of canine appendicular OSA. Median DFI and survival were comparable to those reported in the original Bergman et al publication. Carboplatin treatment improves the survival probability in dogs with appendicular OSA compared to amputation alone and remains an acceptable alternative to adjuvant treatment with cisplatin.






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Copyright © 2009 by the American Animal Hospital Association.