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Journal of the American Animal Hospital Association 45:118-124 (2009)
© 2009 American Animal Hospital Association

Clinical Relevance of Annual Screening Using a Commercial Enzyme-Linked Immunosorbent Assay (SNAP 3Dx) for Canine Ehrlichiosis

Barbara C. Hegarty, BA, Pedro Paulo Vissotto de Paiva Diniz, DVM, PhD, Julie M. Bradley, BA, RVMT, Leif Lorentzen, DVM and Edward Breitschwerdt, DVM, Diplomate ACVIM

From the Intracellular Pathogens Research Laboratory (Hegarty, Diniz, Breitschwerdt) and the Vector Borne Disease Diagnostic Laboratory (Bradley), College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606; andIDEXX Laboratories, Inc. (Lorentzen), One IDEXX Drive, Westbrook, Maine 04092.

Address all correspondence to Dr. Breitschwerdt.

Eighty-six dogs were selected based upon Ehrlichia (E.) canis SNAP 3Dx positive results to determine clinical relevance of annual E. canis screening. Immunofluorescence assay showed 72 (84%) of 86 dogs were seroreactive for E. canis. Polymerase chain reaction (PCR) revealed that 12 (14%) of 86 dogs had Ehrlichia deoxyribonucleic acid; seven had E. canis, four had E. ewingii, and one was coinfected with E. chaffeensis and E. ewingii. Thrombocytopenia (<164,000 platelets/µL) was found in 28 (39%) of 72 dogs. In this study, thrombocytopenia was frequently detected in healthy Ehrlichia SNAP 3Dx-positive dogs, whereas active infection was infrequently confirmed by PCR. Therefore, treatment based upon screening results alone is not recommended.






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